The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects.
10.4196/kjpp.2012.16.4.249
- Author:
Sangil JEON
1
;
Seunghoon HAN
;
Jongtae LEE
;
Taegon HONG
;
Dong Seok YIM
Author Information
1. Department of Pharmacology, College of Medicine, The Catholic University of Korea, Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, Seoul 137-701, Korea. yimds@catholic.ac.kr
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Anthocyanin;
Clinical trial;
C3G;
Pharmacokinetics;
Phaseolus vulgaris
- MeSH:
Anthocyanins;
Glucosides;
Humans;
Phaseolus;
Plasma;
Seeds
- From:The Korean Journal of Physiology and Pharmacology
2012;16(4):249-253
- CountryRepublic of Korea
- Language:English
-
Abstract:
We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h(-1), ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract.
