Assessment of an Apo-1/Fas Promoter Polymorphism in Korean Schizophrenia Patients.
- Author:
Soon Ae KIM
1
;
Youn Jung KIM
;
Bong Keun CHOE
;
Hee Jae LEE
;
Jong Woo KIM
;
Jong Deuk PARK
;
Chang Ju KIM
;
Seung Joon PARK
;
Jee Chang JUNG
;
Joo Ho CHUNG
Author Information
1. Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, Korea. kimsdaughter@ hanmail.net
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Apoptosis;
CD95;
Promoter regions;
Restriction fragment length polymorphism
- MeSH:
Apoptosis;
Humans;
Polymorphism, Restriction Fragment Length;
Promoter Regions, Genetic;
Schizophrenia*
- From:The Korean Journal of Physiology and Pharmacology
2002;6(3):161-164
- CountryRepublic of Korea
- Language:English
-
Abstract:
Apoptosis has been hypothesized to be involved in the pathogenesis in schizophrenia. A large number of genes are known to mediate the apoptotic process; Apo-1/Fas (CD95) is a well-known example of such genes. In the present study, MvaI restriction fragment length polymorphism, a polymorphic marker present within the Apo-1/Fas gene, was examined in a population consisting of 226 control subjects and 110 schizophrenia patients, all of them Korean in ethnicity. No statistically significant difference in the genotypic distribution and allelic frequencies was observed between the control and the schizophrenia patient group. To find out the precise effect of Apo-1/Fas gene polymorphisms on the susceptibility to schizophrenia, further studies are warranted to investigate possible involvement of other polymorphisms with a larger sample population.
