Gradual reperfusion lowers the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia.
- Author:
You Ho KIM
1
;
Heung Sik NA
;
Hyun Jung NAM
;
Gyu Young HUR
;
Seung Whan LEE
;
Sung Sook PARK
;
Seung Kil HONG
Author Information
1. Department of Physiology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu South Korea.
- Publication Type:Original Article
- Keywords:
Gradual reperfusion;
Reperfusion injury;
Reperfusion-induced ventricular fibrillation
- MeSH:
Animals;
Arrhythmias, Cardiac;
Cats*;
Coronary Vessels;
Heart;
Humans;
Incidence*;
Ischemia*;
Male;
Reperfusion Injury;
Reperfusion*;
Transcutaneous Electric Nerve Stimulation;
Ventricular Fibrillation*
- From:The Korean Journal of Physiology and Pharmacology
1999;3(1):47-52
- CountryRepublic of Korea
- Language:English
-
Abstract:
Blood flow restoration to ischemic zone of the heart is essential to salvage of ischemic tissue. However, there is a large body of evidence documenting that the reperfusion can induce reperfusion injury like reperfusion-induced malignant arrhythmias. In the present study, employing a cat model of regional cardiac ischemia, we examined if reperfusion rendered in a gradual fashion could lower the incidence of reperfusion-induced ventricular fibrillation (VF), which usually precipitated within a few to several tens of seconds after abrupt reperfusion. The experiments were conducted with male mongrel cats (n=46, 2.5-5 kg). The animals in the control and 30 MIN groups were subjected to an episode of 20- and 30-min left anterior descending coronary artery occlusion, respectively, followed by abrupt reperfusion. The animals in 5 G and 10 G groups received gradual reperfusion over a 5- and 10-min period, respectively, following a 20-min occlusion. The proportion of animals that exhibited VF during the reperfusion phase was 11/15 in the control, 7/10 in the 30 MIN, 5/10 in the 5 G and 2/11 in the 10 G groups. The incidence of VF in the 10 G group was significantly lower than that in the control or 30 MIN group subjected to abrupt reperfusion. These results suggest that the gradual reperfusion is a useful procedure against reperfusion-induced VF.
