Role of Adenosine in the Activation of Myocardial Catalase Induced by Brief Regional Ischemia .
- Author:
Young Hoon KIM
1
;
Chan Hyung KIM
;
Gi Tae KIM
;
Hong CHOI
;
Jong Wan PARK
;
Myung Suk KIM
Author Information
1. Department of Pharmacology, Seoul National University College of Medicine, 28 Yongon-dong, Chong South Korea.
- Publication Type:Original Article
- Keywords:
Heart;
Ischemia;
Catalase;
Adenosine
- MeSH:
Adenosine*;
Catalase*;
Coronary Vessels;
Hand;
Heart;
Heart Ventricles;
Ischemia*;
Myocardium;
Receptors, Purinergic P1;
Reperfusion;
Theophylline
- From:The Korean Journal of Physiology and Pharmacology
1999;3(1):53-57
- CountryRepublic of Korea
- Language:English
-
Abstract:
The activities of myocardial antioxidant enzymes are known to increase in the hearts preconditioned with the brief episodes of ischemia. This study was undertaken to elucidate the possible involvement of adenosine in the stimulation of myocardial catalase induced by the brief regional ischemia in rabbit hearts. Coronary artery descending the middle anterior wall of left ventricle was occluded for 15 min, followed by 1 hr of reperfusion. Upon reperfusion after the brief ischemia, the activity of catalase increased significantly in both ischemic and non-ischemic parts of myocardium. Pretreatment of the heart with theophylline, a non-specific adenosine receptor blocker, completely abolished the increase of catalase activity in both the ischemic and non-ischemic regions of myocardium. On the other hand, the administration of exogenous adenosine instead of the ischemia failed to increase the catalase activity in in vivo hearts. Moreover, adenosine infusion did not affect the catalase activity in the isolated, perfused hearts either. These results suggest that the endogenous adenosine released from the ischemic myocardium is involved in the activation of catalase induced by brief ischemia, but that adenosine may not be a final direct activator of cellular catalase in the myocardium.
