An integrated review on new targets in the treatment of neuropathic pain.
- Author:
Ravneet Kaur KHANGURA
1
;
Jasmine SHARMA
;
Anjana BALI
;
Nirmal SINGH
;
Amteshwar Singh JAGGI
Author Information
- Publication Type:Review
- Keywords: Endoplasmic reticulum stress receptors; Histone deacetylase; Neuropathic pain; Pain treatment
- MeSH: Adenosine Triphosphatases; Chronic Pain; Cyclic Nucleotide-Gated Cation Channels; Drug Discovery; Endoplasmic Reticulum Stress; Ephrins; Histone Deacetylases; Humans; Models, Animal; Nervous System; Neuralgia*; Oxidoreductases; Receptors, Eph Family; Receptors, sigma
- From:The Korean Journal of Physiology and Pharmacology 2019;23(1):1-20
- CountryRepublic of Korea
- Language:English
- Abstract: Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few medical treatments available for neuropathic pain management and the intolerable side effects of medications may further worsen the symptoms. Despite the presence of profound knowledge that delineates the pathophysiology and mechanisms leading to neuropathic pain, the unmet clinical needs demand more research in this field that would ultimately assist to ameliorate the pain conditions. Efforts are being made globally to explore and understand the basic molecular mechanisms responsible for somatosensory dysfunction in preclinical pain models. The present review highlights some of the novel molecular targets like D-amino acid oxidase, endoplasmic reticulum stress receptors, sigma receptors, hyperpolarization-activated cyclic nucleotide-gated cation channels, histone deacetylase, Wnt/β-catenin and Wnt/Ryk, ephrins and Eph receptor tyrosine kinase, Cdh-1 and mitochondrial ATPase that are implicated in the induction of neuropathic pain. Studies conducted on the different animal models and observed results have been summarized with an aim to facilitate the efforts made in the drug discovery. The diligent analysis and exploitation of these targets may help in the identification of some promising therapies that can better manage neuropathic pain and improve the health of patients.
