Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway.
10.4196/kjpp.2019.23.1.29
- Author:
Seung Tack OH
1
;
Seongmi LEE
;
Cai HUA
;
Byung Soo KOO
;
Sok Cheon PAK
;
Dong Il KIM
;
Songhee JEON
;
Boo Ahn SHIN
Author Information
1. Research Institute, Dongkwang Pharmaceutical Company, Ltd., Seoul 04535, Korea.
- Publication Type:Original Article
- Keywords:
Anti-cancer activity;
Apoptosis;
Cell cycle arrest;
Decursin;
Glioblastoma
- MeSH:
Angelica;
Apoptosis*;
Brain Neoplasms;
Cell Cycle;
Cell Cycle Checkpoints;
Cell Line;
Cyclin D1;
Extracellular Vesicles;
Glioblastoma*;
Glioma;
Neuroglia*;
Plants;
Prostatic Neoplasms
- From:The Korean Journal of Physiology and Pharmacology
2019;23(1):29-35
- CountryRepublic of Korea
- Language:English
-
Abstract:
Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of this plant. In this study, we evaluated the inhibitory activity and related mechanism of action of decursin against glioblastoma cell line. Decursin demonstrated cytotoxic effects on U87 and C6 glioma cells in a dose-dependent manner but not in primary glial cells. Additionally, decursin increased apoptotic bodies and phosphorylated JNK and p38 in U87 cells. Decursin also down-regulated Bcl-2 as well as cell cycle dependent proteins, CDK-4 and cyclin D1. Furthermore, decursin-induced apoptosis was dependent on the caspase activation in U87 cells. Taken together, our data provide the evidence that decursin induces apoptosis in glioblastoma cells, making it a potential candidate as a chemotherapeutic drug against brain tumor.
