In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map.
10.4196/kjpp.2019.23.1.71
- Author:
Ah Jin RYU
1
;
Kyung Eun LEE
;
Soon Sung KWON
;
Eun Seok SHIN
;
Eun Bo SHIM
Author Information
1. SiliconSapiens Co, Seoul 06153, Korea.
- Publication Type:Original Article
- Keywords:
Acute coronary occlusion;
Body surface potential map;
Coronary artery;
Electrophysiology;
In silico
- MeSH:
Cardiac Electrophysiology*;
Computer Simulation*;
Coronary Occlusion;
Coronary Vessels*;
Electrocardiography;
Electrophysiological Phenomena;
Electrophysiology;
Heart;
Heart Diseases;
Humans;
Ischemia;
Torso
- From:The Korean Journal of Physiology and Pharmacology
2019;23(1):71-79
- CountryRepublic of Korea
- Language:English
-
Abstract:
Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart. Therefore, observing electric potential projected to the torso surface can be highly useful for diagnosing heart diseases such as coronary occlusion. The BSPM for the heart of a patient show a higher level of sensitivity than 12-lead ECG. Relevant research has been mostly based on clinical statistics obtained from patients, and, therefore, a simulation for a variety of pathological phenomena of the heart is required. In this study, by using computer simulation, a body surface potential map was implemented according to various occlusion locations (distal, mid, proximal occlusion) in the left anterior descending coronary artery. Electrophysiological characteristics of the body surface during the ST segment period were observed and analyzed based on an ST isointegral map. We developed an integrated system that takes into account the cellular to organ levels, and performed simulation regarding the electrophysiological phenomena of the heart that occur during the first 5 minutes (stage 1) and 10 minutes (stage 2) after commencement of coronary occlusion. Subsequently, we calculated the bipolar angle and amplitude of the ST isointegral map, and observed the correlation between the relevant characteristics and the location of coronary occlusion. In the result, in the ventricle model during the stage 1, a wider area of ischemia led to counterclockwise rotation of the bipolar angle; and, during the stage 2, the amplitude increased when the ischemia area exceeded a certain size.
