Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling.
10.4196/kjpp.2019.23.2.141
- Author:
Donghee LEE
1
;
Yelim SEO
;
Young Won KIM
;
Seongtae KIM
;
Hyemi BAE
;
Jeongyoon CHOI
;
Inja LIM
;
Hyoweon BANG
;
Jung Ha KIM
;
Jae Hong KO
Author Information
1. Department of Physiology, Chung-Ang University College of Medicine, Seoul 06974, Korea. akdongyi01@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Cell movement;
Infrared rays;
Integrins;
Microarray analysis;
Platelet-derived growth factor
- MeSH:
Actins;
Animals;
Cell Movement*;
Extracellular Matrix;
Focal Adhesions;
Gene Expression;
Homeostasis;
Infrared Rays;
Integrins;
Microarray Analysis;
Muscle, Skeletal*;
Platelet-Derived Growth Factor*;
Rats;
Real-Time Polymerase Chain Reaction;
RNA, Messenger;
Wound Healing
- From:The Korean Journal of Physiology and Pharmacology
2019;23(2):141-150
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite increased evidence of bio-activity following far-infrared (FIR) radiation, susceptibility of cell signaling to FIR radiation-induced homeostasis is poorly understood. To observe the effects of FIR radiation, FIR-radiated materials-coated fabric was put on experimental rats or applied to L6 cells, and microarray analysis, quantitative real-time polymerase chain reaction, and wound healing assays were performed. Microarray analysis revealed that messenger RNA expressions of rat muscle were stimulated by FIR radiation in a dose-dependent manner in amount of 10% and 30% materials-coated. In 30% group, 1,473 differentially expressed genes were identified (fold change [FC] > 1.5), and 218 genes were significantly regulated (FC > 1.5 and p < 0.05). Microarray analysis showed that extracellular matrix (ECM)-receptor interaction, focal adhesion, and cell migration-related pathways were significantly stimulated in rat muscle. ECM and platelet-derived growth factor (PDGF)-mediated cell migration-related genes were increased. And, results showed that the relative gene expression of actin beta was increased. FIR radiation also stimulated actin subunit and actin-related genes. We observed that wound healing was certainly promoted by FIR radiation over 48 h in L6 cells. Therefore, we suggest that FIR radiation can penetrate the body and stimulate PDGF-mediated cell migration through ECM-integrin signaling in rats.