Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response.
10.4196/kjpp.2017.21.3.335
- Author:
Kyeong Eun HYUNG
1
;
Soo Jeong KIM
;
Ye Won JANG
;
Da Kyoung LEE
;
Kee Hyeob HYUN
;
Byoung Seok MOON
;
Bongjoon KIM
;
Heeyoon AHN
;
So Young PARK
;
Uy Dong SOHN
;
Eon Sub PARK
;
Kwang Woo HWANG
Author Information
1. College of Pharmacy, Chung-Ang University, Seoul 06974, Korea. khwang@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Atopic;
Dermatitis;
Dermatophagoides farinae;
Lactobacillus;
Probiotics;
Th2 cells
- MeSH:
Animals;
Cytokines;
Dermatitis;
Dermatitis, Atopic*;
Dermatophagoides farinae;
Dust;
Edema;
Eosinophils;
Epidermis;
Hemorrhage;
Immunoglobulin E;
Interferons;
Interleukin-10;
Interleukin-12;
Interleukin-5;
Interleukins;
Lactobacillus;
Lactobacillus plantarum;
Lymph Nodes;
Mast Cells;
Mice;
Probiotics;
Pyroglyphidae;
Skin;
Th2 Cells;
Therapeutic Uses*
- From:The Korean Journal of Physiology and Pharmacology
2017;21(3):335-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-γ, and IL-6,which were stimulated by house dust mite extracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC/Nga mice after onset of the disease by altering immune cell activation. The Lactobacillus strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD.
