Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension.
10.4196/kjpp.2017.21.3.353
- Author:
Tong ZHOU
1
;
Haiyang TANG
;
Ying HAN
;
Dustin FRAIDENBURG
;
Young Won KIM
;
Donghee LEE
;
Jeongyoon CHOI
;
Hyoweon BANG
;
Jae Hong KO
Author Information
1. Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Gene expression;
Hypoxia;
Molecular signature;
Pulmonary hypertension;
VDAC1
- MeSH:
Animals;
Anoxia;
Apoptosis;
Calcium;
Cardiovascular Diseases;
Connective Tissue Diseases;
Fibroblasts;
Gene Expression;
Gene Ontology;
Humans;
Hypertension;
Hypertension, Pulmonary*;
Ion Transport;
Lung Diseases;
Mice;
Mice, Knockout;
Nitric Oxide;
Nitric Oxide Synthase;
Pulmonary Artery;
Transcriptome
- From:The Korean Journal of Physiology and Pharmacology
2017;21(3):353-360
- CountryRepublic of Korea
- Language:English
-
Abstract:
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology. First, we identified the genes differentially expressed between wild-type and Vdac1 knockout mouse embryonic fibroblasts in hypoxic conditions. These genes were deemed to be influenced by VDAC1 deficiency. Gene ontology analysis indicates that the VDAC1 influenced genes are significantly associated with PAH pathobiology. Second, a molecular signature derived from the VDAC1 influenced genes was developed. We suggest that, VDAC1 has a protective role in PAH and the gene expression signature of VDAC1 influenced genes can be used to i) predict severity of pulmonary hypertension secondary to pulmonary diseases, ii) differentiate idiopathic pulmonary artery hypertension (IPAH) patients from controls, and iii) differentiate IPAH from connective tissue disease associated PAH.
