Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation.
10.4196/kjpp.2017.21.4.423
- Author:
Gyoung Wan LEE
1
;
Jae Hyo KIM
;
Min Sun KIM
Author Information
1. Department of Nursing, Wonkwang Health Science University, Iksan 54538, Korea.
- Publication Type:Original Article
- Keywords:
Hippocampus;
Long-term potentiation;
Unilateral labyrinthectomy;
Vestibular compensation
- MeSH:
Animals;
Compensation and Redress*;
Hippocampus*;
Long-Term Potentiation*;
Neuronal Plasticity;
Rats*;
Synapses*
- From:The Korean Journal of Physiology and Pharmacology
2017;21(4):423-428
- CountryRepublic of Korea
- Language:English
-
Abstract:
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer's collateral commissural fibers were evaluated from the CA1 area of hippocampal slices at 1 day, 1 week, and 1 month after unilateral labyrinthectomy (UL). The I/O relationships of fEPSPs in the CA1 area was significantly reduced within 1 week post-op and then showed a non-significant reduction at 1 month after UL. Compared with sham-operated animals, there was a significant reduction of LTP induction in the hippocampus at 1 day and 1 week after UL. However, LTP induction levels in the CA1 area of the hippocampus also returned to those of sham-operated animals 1 month following UL. These data suggest that unilateral injury of the peripheral vestibular end organs results in a transient deficit in synaptic plasticity in the CA1 hippocampal area at acute stages of vestibular compensation.
