Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study.
10.4196/kjpp.2017.21.6.651
- Author:
Hyun Seok BANG
1
;
Dae Yun SEO
;
Young Min CHUNG
;
Do Hyung KIM
;
Sam Jun LEE
;
Sung Ryul LEE
;
Hyo Bum KWAK
;
Tae Nyun KIM
;
Min KIM
;
Kyoung Mo OH
;
Young Jin SON
;
Sanghyun KIM
;
Jin HAN
Author Information
1. Department of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan 48520, Korea.
- Publication Type:Original Article
- Keywords:
Resistance training;
Resistance-trained men;
Skeletal muscle damage markers;
Ursolic acid
- MeSH:
Adipose Tissue;
Body Composition;
Body Weight;
Creatine;
Creatine Kinase;
Healthy Volunteers;
Humans;
Hydrocortisone;
L-Lactate Dehydrogenase;
Male;
Muscle, Skeletal*;
Myoglobin;
Natriuretic Peptide, Brain;
Pilot Projects*;
Resistance Training*
- From:The Korean Journal of Physiology and Pharmacology
2017;21(6):651-656
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.
