Morroniside on anti-inflammation activities in rats following acute myocardial infarction.
10.4196/kjpp.2018.22.1.17
- Author:
Bangxing YU
1
;
Guoxing ZHANG
;
Yi AN
;
Wen WANG
Author Information
1. Department of Experimental Animal Center, XuanWu Hospital of Capital Medical University, Beijing 100053, PR China. lzwwang@163.com
- Publication Type:Original Article
- Keywords:
Acute myocardial infarction;
Cytokine;
Inflammation;
Morroniside
- MeSH:
Animals;
Blotting, Western;
Chloral Hydrate;
Coronary Vessels;
Inflammation;
Interleukin-6;
L-Lactate Dehydrogenase;
Myocardial Infarction*;
Myocardium;
Neuroprotective Agents;
Rats*;
Troponin T
- From:The Korean Journal of Physiology and Pharmacology
2018;22(1):17-21
- CountryRepublic of Korea
- Language:English
-
Abstract:
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.
