Upregulation of Heat Shock Proteins in the Kidney in Hypertension.
- Author:
Geon LEE
1
;
YoonWha OH
;
JongUn LEE
Author Information
1. Department of Physiology, Chonnam National University Medical School, Korea. julee@jnu.ac.kr.
- Publication Type:Original Article
- Keywords:
Heat shock proteins;
Two-kidney;
One clip hypertension;
Deoxycorticosterone acetate-salt hypertension;
Kidney
- MeSH:
Blotting, Western;
Desoxycorticosterone;
Heat-Shock Proteins*;
Hot Temperature*;
Humans;
Hypertension*;
Kidney*;
Male;
Rats, Sprague-Dawley;
Up-Regulation*
- From:The Korean Journal of Physiology and Pharmacology
2004;8(3):147-151
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was undertaken to determine the regulation of heat shock proteins (HSP) in the kidney in hypertension. Two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA) -salt hypertension was induced in male Sprague-Dawley rats. At weeks 1 and 4 after inducing the hypertension, the expression of HSP70, HSP32 and HSP25 was determined in the kidney by Western blot analysis. In 2K1C hypertension, the expression of HSP70, HSP32 and HSP25 was increased in the clipped kidney at both weeks 1 and 4. However, in the contralateral kidney, their expression was not significantly altered at week 1, but increased at week 4. In DOCA-salt hypertension, the expression of HSP remained unaltered in the remnant kidney at week 1, but significantly increased at week 4. These results indicate that HSP are differentially regulated in the kidney according to the duration and the model of hypertension.
