The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function.
- Author:
Hee Sun CHAE
1
;
Yong Koo KANG
;
Yong Kyu SHIN
;
Hyun Jung LEE
;
Ji In YU
;
Kwang Gill LEE
;
Joo Hong YEO
;
Yong Sik KIM
;
Dong Suep SOHN
;
Kyung Yong KIM
;
Won Bok LEE
;
Sang Hyung LEE
;
Sung Su KIM
Author Information
1. Department of Anatomy, College of Medicine, Chung-Ang University, Seoul, Korea. sungsu@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Brain;
Learning and memory;
BF-7;
Natural product;
Amyloid
- MeSH:
Alzheimer Disease;
Amyloid;
Amyloid beta-Peptides;
Apoptosis;
Brain;
Cognition;
Humans;
Learning;
Memory;
Neurons
- From:The Korean Journal of Physiology and Pharmacology
2004;8(4):173-179
- CountryRepublic of Korea
- Language:English
-
Abstract:
Amyloid beta-peptide (A beta) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against A beta -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated A beta-induced apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.
