Physiological and pharmacological characterization of glutamate and GABA receptors in the retina.
- Author:
Xiong Li YANG
1
;
Ying SHEN
;
Ming Hu HAN
;
Tao LU
Author Information
1. Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, 200031 China.
- Publication Type:Original Article
- Keywords:
Retina;
Glutamate;
gamma-aminobutyric acid;
Desensitization;
Receptor;
Patch-clamp
- MeSH:
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;
Amacrine Cells;
Carps;
gamma-Aminobutyric Acid*;
Glutamic Acid*;
Kinetics;
Neurotransmitter Agents;
Receptors, GABA*;
Receptors, Glutamate;
Retina*;
Vertebrates
- From:The Korean Journal of Physiology and Pharmacology
1999;3(5):461-469
- CountryRepublic of Korea
- Language:English
-
Abstract:
Glutamate and gamma-aminobutyric acid (GABA) are major excitatory and inhibitory neurotransmitters in the vertebrate retina, respectively. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors have been extensively investigated in carp retina. Glutamate receptors on both horizontal and amacrine cells may be an AMPA preferring subtype, which predominantly consists of flop splice variants. GABAA and GABAC receptors coexist in bipolar cells and they both show significant desensitization. Kinetics analysis demonstrated that activation, deactivation and desensitization of the GABAC receptor-mediated response of these cells are overall slower than those of the GABAA response. Endogenous modulator Zn2+ in the retina was found to differentially modulate the kinetic characteristics of the GABAC and GABAA responses.
