Effect of cytokines and bFGF on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures.
- Author:
Han Jung CHAE
1
;
Jang Sook KANG
;
Byung Gwan BANG
;
Seoung Bum CHO
;
Jo IL HAN
;
Joo Young CHOI
;
Hyung Min KIM
;
Soo Wan CHAE
;
Hyung Ryong KIM
Author Information
1. Department of Dental Pharmacology, Wonkwang University School of Dentistry, Iksan, Chonbuk, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Cytokines;
Basic fibroblast growth factor;
Bone marrow;
Osteoclast formation
- MeSH:
Bone and Bones;
Bone Marrow*;
Bone Remodeling;
Calcium;
Cytokines*;
Fibroblast Growth Factor 2;
Homeostasis;
Interleukin-1beta;
Interleukin-3;
Interleukin-4;
Macrophages;
Osteoblasts;
Osteoclasts*;
Osteoporosis;
Periodontal Diseases;
Stromal Cells;
T-Lymphocytes;
Tumor Necrosis Factor-alpha
- From:The Korean Journal of Physiology and Pharmacology
1999;3(6):539-546
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly responsible for bone remodeling. Periodontal disease represents example of abnormal bone remodeling. Osteoclasts are multinucleated cells present only in bone. It is believed that osteoclast progenitors are hematopoietic origin, and they are recruited from hematopoietic tissues such as bone marrow and circulating blood to bone. Cells present in the osteoclast microenvironment include marrow stromal cells, osteoblasts, macrophages, T-lymphocytes, and marrow cells. These cells produce cytokines that can affect osteoclast formation. In vitro model systems using bone marrow cultures have demonstrated that IL-1 beta, IL-3, TNF-alpha, bFGF can stimulate the formation of osteoclasts. In contrast, IL-4 inhibits osteoclast formation. Knowledge of cytokines and bFGF that affect osteoclast formation and their capacity to modulate the bone-resorbing process should provide critical insights into normal calcium homeostasis and disorders of bone turnover such as periodontal disease, osteoporosis and Paget's disease.
