Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node.
10.4196/kjpp.2010.14.5.249
- Author:
Hiroyasu SATOH
1
;
Setsuko TOHNO
;
Takeshi MINAMI
;
Takao OISHI
;
Motoharu HAYASHI
;
Yoshiyuki TOHNO
Author Information
1. Department of Pharmacology, Division of Molecular and Cellular Biology, Kashihara, Nara University 634-8521, Japan. hysat@naramed-u.ac.jp
- Publication Type:Original Article
- Keywords:
Gender difference;
Trace elements;
Age-dependent alteration;
Cardiac pacemaker;
Monkey sino-atrial node
- MeSH:
Adult;
Aged;
Asian Continental Ancestry Group;
Female;
Haplorhini;
Heart;
Humans;
Macaca mulatta;
Male;
Sinoatrial Node;
Trace Elements
- From:The Korean Journal of Physiology and Pharmacology
2010;14(5):249-256
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were -0.178+/-0.081 (p<0.05) and -0.088+/-0.022 (p<0.05) in male (n=30), and -0.095+/-0.026 (p<0.05) and -0.069+/-0.017 (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.