Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus.
10.4196/kjpp.2010.14.5.257
- Author:
Min Soo KWON
1
;
Jin Koo LEE
;
Soo Hyun PARK
;
Yun Beom SIM
;
Jun Sub JUNG
;
Moo Ho WON
;
Seon Mi KIM
;
Hong Won SUH
Author Information
1. Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea. hwsuh@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Neuroprotection;
Kainic acid;
Hippocampus;
Visnagin;
Cytokines
- MeSH:
Ammi;
Animals;
Benzoxazines;
Blood Cells;
Blood Vessels;
Brain;
Calcium;
Cell Death;
Contracts;
Cytokines;
Fruit;
Gliosis;
Glycosaminoglycans;
Hippocampus;
Interleukin-6;
Kainic Acid;
Khellin;
Mice;
Neurons;
Neuroprotective Agents;
Tumor Necrosis Factor-alpha;
Viola
- From:The Korean Journal of Physiology and Pharmacology
2010;14(5):257-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of visnagin was not clearly known until now. Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet staining, pre-treatment or post-treatment visnagin (100 mg/kg, p.o. or i.p.) showed a neuroprotective effect on KA (0.1 microgram) toxicity. KA-induced gliosis and proinflammatory marker (IL-1beta, TNF-alpha, IL-6, and COX-2) inductions were also suppressed by visnagin administration. These results suggest that visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects.
