MR Diagnosis of a Pulmonary Embolism: Comparison of P792 and Gd-DOTA for First-Pass Perfusion MRI and Contrast-Enhanced 3D MRA in a Rabbit Model.
10.3348/kjr.2009.10.5.447
- Author:
Shella D KEILHOLZ
1
;
Ugur BOZLAR
;
Naomi FUJIWARA
;
Jaime F MATA
;
Stuart S BERR
;
Claire COROT
;
Klaus D HAGSPIEL
Author Information
1. Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Pulmonary embolism;
P792;
Angiography, perfusion
- MeSH:
Animals;
Contrast Media/administration & dosage;
Heterocyclic Compounds/administration & dosage/*diagnostic use;
Imaging, Three-Dimensional;
Injections, Intravenous;
Magnetic Resonance Angiography/*methods;
Magnetic Resonance Imaging/*methods;
Organometallic Compounds/administration & dosage/*diagnostic use;
Pulmonary Embolism/*diagnosis;
Rabbits
- From:Korean Journal of Radiology
2009;10(5):447-454
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To compare P792 (gadomelitol, a rapid clearance blood pool MR contrast agent) with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), a standard extracellular agent, for their suitability to diagnose a pulmonary embolism (PE) during a first-pass perfusion MRI and 3D contrast-enhanced (CE) MR angiography (MRA). MATERIALS AND METHODS: A perfusion MRI or CE-MRA was performed in a rabbit PE model following the intravenous injection of a single dose of contrast agent. The time course of the pulmonary vascular and parenchymal enhancement was assessed by measuring the signal in the aorta, pulmonary artery, and lung parenchyma as a function of time to determine whether there is a significant difference between the techniques. CE-MRA studies were evaluated by their ability to depict the pulmonary vasculature and following defects between 3 seconds and 15 minutes after a triple dose intravenous injection of the contrast agents. RESULTS: The P792 and Gd-DOTA were equivalent in their ability to demonstrate PE as perfusion defects on first pass imaging. The signal from P792 was significantly higher in vasculature than that from Gd-DOTA between the first and the tenth minutes after injection. The results suggest that a CE-MRA PE could be reliably diagnosed up to 15 minutes after injection. CONCLUSION: P792 is superior to Gd-DOTA for the MR diagnosis of PE.
