Effect of the Heat-exposure on Peripheral Sudomotor Activity Including the Density of Active Sweat Glands and Single Sweat Gland Output.
10.4196/kjpp.2010.14.5.273
- Author:
Jeong Beom LEE
1
;
Tae Wook KIM
;
Young Oh SHIN
;
Young Ki MIN
;
Hun Mo YANG
Author Information
1. Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan 331-946, Korea. leejb@sch.ac.kr
- Publication Type:Original Article
- Keywords:
Short-term heat-acclimatization;
Sudomotor axon reflex;
Active sweat gland;
Single sweat gland output;
Acetylcholine
- MeSH:
Acetylcholine;
Axons;
Forearm;
Hot Temperature;
Iontophoresis;
Neurotransmitter Agents;
Receptors, Cholinergic;
Reflex;
Skin;
Skin Temperature;
Sweat;
Sweat Glands;
Sweating;
Tropical Climate
- From:The Korean Journal of Physiology and Pharmacology
2010;14(5):273-278
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tropical inhabitants are able to tolerate heat through permanent residence in hot and often humid tropical climates. The goal of this study was to clarify the peripheral mechanisms involved in thermal sweating pre and post exposure (heat-acclimatization over 10 days) by studying the sweating responses to acetylcholine (ACh), a primary neurotransmitter of sudomotor activity, in healthy subjects (n=12). Ten percent ACh was administered on the inner forearm skin for iontophoresis. Quantitative sudomotor axon reflex testing, after iontophoresis (2 mA for 5 min) with ACH, was performed to determine directly activated (DIR) and axon reflex-mediated (AXR) sweating during ACh iontophoresis. The sweat rate, activated sweat gland density, sweat gland output per single gland activated, as well as oral and skin temperature changes were measured. The post exposure activity had a short onset time (p<0.01), higher active sweat rate [(AXR (p<0.001) and DIR (p<0.001)], higher sweat output per gland (p<0.001) and higher transepidermal water loss (p<0.001) compared to the pre-exposure measurements. The activated sweat rate in the sudomotor activity increased the output for post-exposure compared to the pre-exposure measurements. The results suggested that post-exposure activity showed a higher active sweat gland output due to the combination of a higher AXR (DIR) sweat rate and a shorter onset time. Therefore, higher sudomotor responses to ACh receptors indicate accelerated sympathetic nerve responsiveness to ACh sensitivity by exposure to environmental conditions.
