Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex.
- Author:
Hwang Soo KIM
1
;
Hyun Sok KIM
;
Sang June HAHN
;
Myung Jun KIM
;
Shin Hee YOON
;
Yang Hyeok JO
;
Myung Suk KIM
;
Duck Joo RHIE
Author Information
1. Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea. djrhie@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Serotonin;
Fluoxetine;
Long-term potentiation;
Frontal cortex
- MeSH:
Animals;
Baths;
Fluoxetine*;
Hippocampus;
Long-Term Potentiation*;
N-Methylaspartate;
p-Chloroamphetamine;
Prefrontal Cortex;
Rats*;
Serotonin;
Visual Cortex
- From:The Korean Journal of Physiology and Pharmacology
2004;8(6):295-300
- CountryRepublic of Korea
- Language:English
-
Abstract:
Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 (50microM), an NMDA receptor antagonist. Whereas bath application of 5-HT (10microM) inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine (PCA, 10microM), for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and 10microM) suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.
