The Improvement of Learning and Memory Ability of Normal Persons by BF-7.
- Author:
Sang Hyung LEE
1
;
Yong Sik KIM
;
Yong Koo KANG
;
Oh Sang KWON
;
Yong Kyoo SHIN
;
Jin Ho SONG
;
Moo Yeol LEE
;
Kwang Gill LEE
;
Joo Hong YEO
;
Won Bok LEE
;
Tae Jin LEE
;
Sung Su KIM
Author Information
1. Department of Neurosurgery, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Brain;
Learning and memory;
BF-7;
Acetylcholine;
Neuroprotection
- MeSH:
Acetylcholine;
Bombyx;
Brain;
Cholinergic Neurons;
Humans;
Learning*;
Memory*;
Models, Animal
- From:The Korean Journal of Physiology and Pharmacology
2004;8(6):307-312
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
