Renal handling of sodium and potassium in cadmium exposed rats.
- Author:
Yung Kyu KIM
1
;
Yang Saeng PARK
Author Information
1. Department of Physiology, Dongguk University College of Medicine, Kyungju 780-714, South Korea.
- Publication Type:Original Article
- Keywords:
Cadmium;
Renal function;
Na+ excretion;
K+ excretion;
Lithium clearance
- MeSH:
Animals;
Cadmium*;
Lithium;
Nephrons;
Potassium*;
Rats*;
Sodium*
- From:The Korean Journal of Physiology and Pharmacology
1998;2(4):503-510
- CountryRepublic of Korea
- Language:English
-
Abstract:
Effects of cadmium exposure on renal Na+ and K+ transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of Na+ and K+ were evaluated by lithium clearance technique. During the early phase (first week) of cadmium treatment, urinary Na+ excretion decreased drastically and this was due to an increased Na+ reabsorption both in the proximal and distal nephrons. During the late phase (third week) of cadmium treatment, filtered Na+ load was decreased by reduction in GFR, but the renal Na+ excretion returned to the control level due to impaired Na+ transport in the proximal tubule. Urinary excretion of K+ did not change during the early phase, but it rose markedly during the late phase of cadmium treatment. These results indicate that a light cadmium intoxication induces a Na+ retention, and a heavy intoxication results in a K+ loss. Possible mechanisms for these changes are discussed.
