Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs.
10.4196/kjpp.2013.17.4.267
- Author:
Yu Ji CHO
1
;
Chin Ok YI
;
Byeong Tak JEON
;
Yi Yeong JEONG
;
Gi Mun KANG
;
Jung Eun LEE
;
Gu Seob ROH
;
Jong Deog LEE
Author Information
1. Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-290, Korea. ljd8611@empal.com
- Publication Type:Original Article
- Keywords:
Curcumin;
Fibrosis;
Inflammation;
Lung;
Radiation
- MeSH:
Animals;
Blotting, Western;
Collagen;
Connective Tissue Growth Factor;
Curcumin;
Cyclooxygenase 2;
Edema;
Fibrosis;
Inflammation;
Lung;
Lung Injury;
Macrophages;
Pneumonia;
Rats;
Receptors, Tumor Necrosis Factor;
Tumor Necrosis Factor-alpha
- From:The Korean Journal of Physiology and Pharmacology
2013;17(4):267-274
- CountryRepublic of Korea
- Language:English
-
Abstract:
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, and collapse in radiation-treated lungs were inhibited by curcumin administration. Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin. Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2). Curcumin also inhibited the nuclear translocation of nuclear factor-kappa B (NF-kappaB) p65 in radiation-treated lungs. These results indicate that long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.
