Effect of Lutein on L-NAME-Induced Hypertensive Rats.
10.4196/kjpp.2013.17.4.339
- Author:
Ji Hoon SUNG
1
;
Young Soo JO
;
Su Jin KIM
;
Jeong Soo RYU
;
Myung Chul KIM
;
Hyun Ju KO
;
Sang Soo SIM
Author Information
1. College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. simss@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Antioxidant;
Hypertension;
Lipid peroxidation;
L-NAME;
Lutein
- MeSH:
Administration, Oral;
Animals;
Antioxidants;
Arterial Pressure;
Blood Pressure;
Glutathione;
Heart;
Heart Rate;
Hypertension;
Hypertrophy;
Kidney;
Lipid Peroxidation;
Lutein;
NG-Nitroarginine Methyl Ester;
Plasma;
Rats
- From:The Korean Journal of Physiology and Pharmacology
2013;17(4):339-345
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3+/-9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434+/-26 to 376+/-33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.
