Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction.
10.4196/kjpp.2014.18.2.177
- Author:
Lujin LI
1
;
Zhenghua JIA
;
Ling XU
;
Yiling WU
;
Qingshan ZHENG
Author Information
1. The Center for Drug Clinical Research, Shanghai University of Chinese Medicine, Shanghai, China. qingshan.zheng@drugchina.net
- Publication Type:Original Article
- Keywords:
Endocrine system;
Immune system;
Nervous system;
Vascular endothelial dysfunction
- MeSH:
Animals;
Diet, High-Fat;
Endocrine System;
Homocysteine;
Humans;
Immune System;
Male;
Nervous System;
Rats*;
Rats, Wistar;
Risk Factors;
Simvastatin
- From:The Korean Journal of Physiology and Pharmacology
2014;18(2):177-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
