Melatonin enhances hepatic glutathione-peroxidase activity in Sprague-Dawley rats.
- Author:
Choong Yong KIM
1
;
Choong Soon YUN
;
Dae Hun PARK
;
Woo Sung CHOI
;
Jin Suk KIM
Author Information
1. Pharmacol. and Toxicol. Lab., Dep. Vet. Med. and ARRC, Kon-Kuk University, 93-1 Mojin-Dong, Kwangjin- South Korea.
- Publication Type:Original Article
- Keywords:
Melationin;
Hepatic glutathione-peroxidase;
Plasma
- MeSH:
Animals;
Cytosol;
Lipid Peroxidation;
Lipid Peroxides;
Liver;
Melatonin*;
Membranes;
Plasma;
Rats;
Rats, Sprague-Dawley*
- From:The Korean Journal of Physiology and Pharmacology
1997;1(2):221-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
Effects of melatonin on hepatic glutathione-peroxidase (GSH-Px) and glutathione-reductase (GSH-reductase) activities were studied in Sprague-Dawley (SD) rats administered i.p. (10 mg/kg body weight) with melatonin during 15 days. The activity of cytosolic GSH-reductase in the liver was not changed by melatonin. However, melatonin injection increased significantly the activity of liver cytosolic GSH-Px activity compared with those in saline-treated rats. At the same time, plasma GSH-Px was also increased significantly in melatonin-treated rats. Since GSH-Px, a major antioxidative enzyme, removes H-2O-2 and lipid peroxides which are formed during lipid peroxidation from cellular membrane, such elevation of heptatic GSH-Px activity may contribute to the improvement of antioxidative effects under oxidative damage in the liver.
