Inhibitory effects of reversible proton pump inhibitors YH 1238 and YH1885 on acid secretion in isolated gastric cells.
- Author:
Hyeyoung KIM
1
;
Dong Goo KIM
;
Bong Yong LEE
;
Jong Wook LEE
;
Kyung Hwan KIM
Author Information
1. Department of Pharmacology, Yonsei University, College of Medicine , Seoul South Korea.
- Publication Type:Original Article
- Keywords:
Antiulcer;
YH1238;
YH1885;
Acid secretion;
Gastric cells
- MeSH:
Humans;
Omeprazole;
Proton Pump Inhibitors*;
Proton Pumps*;
Protons*;
Stomach
- From:The Korean Journal of Physiology and Pharmacology
1997;1(3):337-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of (14C)-aminopyrine and (14C)-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP (10(-3) M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the (14C)-aminopyrine accumulation and (14C)-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on (14C)-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10(-5) M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.
