Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis.
10.3347/kjp.2016.54.6.719
- Author:
Shabnam TADAYON
1
;
Seyed Mostafa RAZAVI
;
Saeed NAZIFI
Author Information
1. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, 1731, Shiraz 71345, Iran.
- Publication Type:Original Article
- Keywords:
Eimeria caprina;
Eimeria ninakohlyakimovae;
Eimeria arloingi;
systemic innate immunity;
inflammatory factor;
caprine coccidiosis
- MeSH:
Acute-Phase Proteins;
Aging;
Animals;
Coccidiosis*;
Cytokines;
Immunity, Innate*;
Inflammation;
Interleukin-4;
Interleukin-6;
Oocysts
- From:The Korean Journal of Parasitology
2016;54(6):719-724
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×104 sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.
