The Pathophysiologic Roles of TRPM7 Channel.
10.4196/kjpp.2014.18.1.15
- Author:
Hyun Soo PARK
1
;
Chansik HONG
;
Byung Joo KIM
;
Insuk SO
Author Information
1. Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 626-870, Korea. vision@pusan.ac.kr
- Publication Type:Review
- Keywords:
Disease;
Ion Channel;
Transient receptor potential melastatin 7;
TRPM7
- MeSH:
Cell Death;
Cell Proliferation;
Ion Channels;
Muscle, Smooth, Vascular;
Nucleotides;
Phosphotransferases
- From:The Korean Journal of Physiology and Pharmacology
2014;18(1):15-23
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2+ and Ca2+, and its channel activity is negatively regulated by free Mg2+ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.
