Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse.
10.4196/kjpp.2014.18.1.33
- Author:
Woo Jin CHOI
1
;
Seong Keun KIM
;
Hee Kuk PARK
;
Uy Dong SOHN
;
Wonyong KIM
Author Information
1. Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-861, Korea. kimwy@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Anti-inflammatory effect;
Antimicrobial activity;
Cytokine;
RAW 264.7 murine macrophages;
Shepherd's purse;
Sulforaphane
- MeSH:
Asia;
Bacillus anthracis;
Capsella*;
Cyclooxygenase 2;
Cytokines;
Dinoprostone;
Functional Food;
Food, Organic;
Interleukin-6;
Macrophages;
Nitric Oxide;
Nitric Oxide Synthase
- From:The Korean Journal of Physiology and Pharmacology
2014;18(1):33-39
- CountryRepublic of Korea
- Language:English
-
Abstract:
Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd's purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1beta [IL-1beta], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti-inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 microg/ml for VRE and 1,000 microg/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical.
