The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice.
10.4196/kjpp.2014.18.1.41
- Author:
Yun Beom SIM
1
;
Soo Hyun PARK
;
Sung Su KIM
;
Chea Ha KIM
;
Su Jin KIM
;
Su Min LIM
;
Jun Sub JUNG
;
Ohk Hyun RYU
;
Moon Gi CHOI
;
Hong Won SUH
Author Information
1. Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea. hwsuh@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Blood glucose;
D-glucose;
Histamine receptors;
Spinal cord
- MeSH:
Animals;
Blood Glucose*;
Cetirizine;
Dimaprit;
Down-Regulation;
Glucose;
Histamine*;
Mice*;
Mice, Inbred ICR;
Ranitidine;
Receptors, Histamine H2;
Receptors, Histamine H3;
Receptors, Histamine*;
Spinal Cord;
Up-Regulation
- From:The Korean Journal of Physiology and Pharmacology
2014;18(1):41-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor agonist (2-pyridylethylamine) or antagonist (cetirizine), histamine 2 (H2) receptor agonist (dimaprit) or antagonist (ranitidine), histamine 3 (H3) receptor agonist (alpha-methylhistamine) or antagonist (carcinine) and histamine 4 (H4) receptor agonist (VUF 8430) or antagonist (JNJ 7777120), and the blood glucose level was measured at 30, 60 and 120 min after i.t. administration. The i.t. injection with alpha-methylhistamine, but not carcinine slightly caused an elevation of the blood glucose level. In addition, histamine H1, H2, and H4 receptor agonists and antagonists did not affect the blood glucose level. In D-glucose-fed model, i.t. pretreatment with cetirizine enhanced the blood glucose level, whereas 2-pyridylethylamine did not affect. The i.t. pretreatment with dimaprit, but not ranitidine, enhanced the blood glucose level in D-glucose-fed model. In addition, alpha-methylhistamine, but not carcinine, slightly but significantly enhanced the blood glucose level D-glucose-fed model. Finally, i.t. pretreatment with JNJ 7777120, but not VUF 8430, slightly but significantly increased the blood glucose level. Although histamine receptors themselves located at the spinal cord do not exert any effect on the regulation of the blood glucose level, our results suggest that the activation of spinal histamine H2 receptors and the blockade of spinal histamine H1 or H3 receptors may play modulatory roles for up-regulation and down-regulation, respectively, of the blood glucose level in D-glucose fed model.
