Dehydroevodiamine.HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats.
10.4196/kjpp.2014.18.1.55
- Author:
Hee Jin KIM
1
;
Ki Young SHIN
;
Keun A CHANG
;
Sangzin AHN
;
Hee Soon CHOI
;
Hye Sun KIM
;
Yoo Hun SUH
Author Information
1. Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea.
- Publication Type:Original Article
- Keywords:
Depression;
DHED;
Fluoxetine;
Memory;
Stress
- MeSH:
Animals;
Cell Survival;
Depression*;
Fluoxetine;
Memory*;
Models, Animal;
Neural Cell Adhesion Molecules;
Neurons;
Physical Exertion;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
2014;18(1):55-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dehydroevodiamine.HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.
