Lipidomic analysis of plasma lipids composition changes in septic mice.
10.4196/kjpp.2018.22.4.399
- Author:
Won Gyun AHN
1
;
Jun Sub JUNG
;
Dong Keun SONG
Author Information
1. Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chuncheon 24252, Korea. dksong@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Lipidomics;
Mice;
Plasma;
Sepsis
- MeSH:
Animals;
Biomarkers;
Ligation;
Lysophosphatidylcholines;
Mice*;
Peritonitis;
Phosphatidic Acids;
Phosphatidylcholines;
Phosphatidylinositols;
Plasma*;
Punctures;
Sepsis
- From:The Korean Journal of Physiology and Pharmacology
2018;22(4):399-408
- CountryRepublic of Korea
- Language:English
-
Abstract:
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE], phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride [TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.
