Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock.
10.3347/kjp.2016.54.6.769
- Author:
Jianrong YE
1
;
Qin ZHANG
;
Yan XUAN
;
Siyu CHEN
;
Long MA
;
Yongqiang ZHANG
;
Hong ZHENG
Author Information
1. Department of Anesthesiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, P. R. China. hzhengxj@sina.com
- Publication Type:Original Article
- Keywords:
Echinococcus granulosus;
cystic echinococcosis;
hydatid cyst;
anaphylaxis;
surgery;
zoonotic infectious disease
- MeSH:
Anaphylaxis*;
Area Under Curve;
Case-Control Studies;
Echinococcosis;
Echinococcus granulosus;
Humans;
Interleukin-4;
Multivariate Analysis;
Retrospective Studies;
ROC Curve;
Sensitivity and Specificity;
Zoonoses
- From:The Korean Journal of Parasitology
2016;54(6):769-775
- CountryRepublic of Korea
- Language:English
-
Abstract:
This retrospective case-control study explored the factors associated with anaphylactic shock during surgery for cystic echinococcosis (CE) at the First Affiliated Hospital of Xinjiang Medical University between October 2008 and September 2013. Patients who suffered from anaphylactic shock (n=16) were age-matched 3:1 to patients who did not (n=43). Multivariate analysis suggested that IL-4 levels (odds ratio=1.096; 95% confidence interval=1.015–1.185; P=0.02) and cyst size (odds ratio=3.028, 95% confidence interval=1.259–7.283, P=0.013) were independently associated with CE-induced perioperative anaphylactic shock. Using the receiver operating characteristic (ROC) curves and a cut-off value of 415.7 ng/ml, IL-4 showed an area under the ROC (AUC) of 0.926, sensitivity of 75.0%, and specificity of 97.7%. Using a cut-off value of 7.8 cm, cyst size showed an AUC of 0.828, sensitivity of 81.3%, and specificity of 76.7%. In conclusion, results suggest that levels of IL-4 and cyst size were independently associated with echinococcosis-induced perioperative anaphylactic shock. These results could help identifying patients with echinococcosis at risk of anaphylactic shock in whom appropriate prophylaxis could be undertaken.
