Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse.
10.4196/kjpp.2012.16.2.119
- Author:
Soo Hyun PARK
1
;
Yun Beom SIM
;
Yu Jung KANG
;
Jin Koo LEE
;
Soon Sung LIM
;
Hong Won SUH
Author Information
1. Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea. hwsuh@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Agrimonia pilosa Ledeb;
Anti-nociception;
Inflammatory pain;
alpha2 adrenoceptor
- MeSH:
Agrimonia;
Animals;
Methysergide;
Mice;
Mice, Inbred ICR;
Naloxone;
Reaction Time;
Substance P;
Yohimbine
- From:The Korean Journal of Physiology and Pharmacology
2012;16(2):119-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 microg) was diminished by Agrimonia pilosa Ledeb extract. Intraperitoneal (i.p.) pretreatment with yohimbine (alpha2-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Agrimonia pilosa Ledeb extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Agrimonia pilosa Ledeb extract in the writhing test. Our results suggest that Agrimonia pilosa Ledeb extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Agrimonia pilosa Ledeb extract may be mediated by alpha2-adrenergic receptor, but not opioidergic and serotonergic receptors.
