Inhibitory effects of ginseng saponins on c-fos mRNA expression and the proliferation of rat aortic vascular smooth muscle cells stimulated by angiotensin II.
- Author:
Woong CHOI
1
;
Jin Young JUNG
;
Hun Sik KIM
;
Yeo Pyo YUN
;
Jong Dae PARK
;
Hee Yul AHN
Author Information
1. Department of Pharmacology, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea.
- Publication Type:Original Article
- Keywords:
Ginseng saponins;
c-fos;
Proliferation;
Angiotensin II;
Vascular smooth muscle cells
- MeSH:
Angiotensin II*;
Angiotensins*;
Animals;
Atherosclerosis;
Hypertension;
Muscle, Smooth, Vascular*;
Panax*;
Rats*;
RNA, Messenger*;
Saponins*
- From:The Korean Journal of Physiology and Pharmacology
1998;2(2):201-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate the possibility that the ginseng saponins could be developed as an anti-arteriosclerotic agent, we examined the inhibitory effects of ginseng saponins (total saponin(TS), panaxatriol(PT), panaxadiol(PD)) on the expression of c-fos mRNA and the proliferation of cultured rat aortic vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II). TS and PT (1.0 mg/ml) suppressed c-fos mRNA induction in VSMCs stimulated by 10-5 M Ang II. The order of inhibitory potency was PT>TS. Ginseng saponins (0.01~1.0 mg/ml) inhibited the proliferation of VSMCs stimulated by Ang II in a concentration dependent manner, the inhibitory potency was TS> PT> PD at 0.1~1.0 mg/ml. These results suggest that ginseng saponins may suppress Ang II-stimulated proliferation of aortic VSMCs which can be seen in atherosclerosis, hypertension and restenosis.
