Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats.
10.4196/kjpp.2013.17.5.411
- Author:
Wi Joon IM
1
;
Yoonjin NAM
;
Sun Young PARK
;
Uy Dong SOHN
Author Information
1. Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. udsohn@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Flavonoids;
Gastritis;
Lipid peroxidation
- MeSH:
Animals;
Flavonoids*;
Gastritis;
Indomethacin;
Lipid Peroxidation;
Omeprazole;
Oxidative Stress;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
2013;17(5):411-415
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID50 was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each ID50 was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats.
