Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats.
10.4196/kjpp.2013.17.5.469
- Author:
Se Eun LEE
1
;
Hyun Ju SONG
;
Sun Young PARK
;
Yoonjin NAM
;
Chang Ho MIN
;
Do Yeon LEE
;
Jun Yeong JEONG
;
Hyun Su HA
;
Hyun Jung KIM
;
Wan Kyun WHANG
;
Ji Hoon JEONG
;
In Kyeom KIM
;
Hak Rim KIM
;
Young Sil MIN
;
Uy Dong SOHN
Author Information
1. Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. udsohn@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Chronic gastritis;
Iodoacetamide;
QGC;
Reactive oxygen species;
Superoxide dismutase
- MeSH:
Animals;
Body Weight;
Drinking;
Gastric Mucosa;
Gastritis*;
Glutathione;
Iodoacetamide*;
Lipid Peroxidation;
Malondialdehyde;
Neutrophil Infiltration;
Peroxidase;
Quercetin*;
Rats*;
Reactive Oxygen Species;
Rumex;
Superoxide Dismutase
- From:The Korean Journal of Physiology and Pharmacology
2013;17(5):469-477
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study investigated effect of extract containing quercetin-3-O-beta-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.
