Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells.
10.4196/kjpp.2009.13.6.417
- Author:
Young Ran PARK
1
;
Jae Soon EUN
;
Hwa Jung CHOI
;
Manoj NEPAL
;
Dae Keun KIM
;
Seung Yong SEO
;
Rihua LI
;
Woo Sung MOON
;
Nam Pyo CHO
;
Sung Dae CHO
;
Tae Sung BAE
;
Byung Il KIM
;
Yunjo SOH
Author Information
1. Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University, Jeon-Ju 561-756, Korea. ysoh@jbnu.ac.kr
- Publication Type:Original Article
- Keywords:
Ficus carica;
Osteoclast differentiation;
RAW264.7 cells;
Bone marrow-derived macrophages;
Bone lytic diseases
- MeSH:
Arthritis, Rheumatoid;
Bone Resorption;
Carica;
Ficus;
Macrophages;
Myeloid Progenitor Cells;
NF-kappa B;
Osteoclasts;
Osteoporosis;
Receptor Activator of Nuclear Factor-kappa B
- From:The Korean Journal of Physiology and Pharmacology
2009;13(6):417-424
- CountryRepublic of Korea
- Language:English
-
Abstract:
Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast development depends critically on a differentiation factor, the receptor activator of NF-kappaB ligand (RANKL). In this study, we found that the hexane soluble fraction of the common fig Ficus carica (HF6-FC) is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW264.7 cells and in bone marrow-derived macrophages (BMMs). HF6-FC exerts its inhibitory effects by suppression of p38 and NF-kappaB but activation of ERK. In addition, HF6-FC significantly decreased the expression of NFATc1 and c-Fos, the master regulator of osteoclast differentiation. The data indicate that components of HF6-FC may have therapeutic effects on bone-destructive processes such as osteoporosis, rheumatoid arthritis, and periodontal bone resorption.
