Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones.
10.4196/kjpp.2009.13.6.511
- Author:
Yong Jin KIM
1
;
Eun Ae KIM
;
Mi Lyang CHUNG
;
Chaeuk IM
Author Information
1. College of Pharmacy, Chung-ang University, Seoul 156-756, Korea. Chaeukim@cau.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
CoMFA;
CoMSIA;
Cytotoxicity;
MTT;
QSAR
- MeSH:
Cell Line, Tumor;
Colchicine;
Cytotoxins;
Humans;
Inhibitory Concentration 50;
Kidney Neoplasms;
Lung Neoplasms;
Quantitative Structure-Activity Relationship
- From:The Korean Journal of Physiology and Pharmacology
2009;13(6):511-516
- CountryRepublic of Korea
- Language:English
-
Abstract:
A series of substituted 2-arylnaphthyridin-4-one analogues, which were previously synthesized in our laboratory, were evaluated for their in vitro cytotoxic activity against human lung cancer A549 and human renal cancer Caki-2 cells using MTT assay. Some compounds (11, 12, and 13) showed stronger cytotoxicity than colchicine against both tumor cell lines, and compound 13 exhibited the most potent activity with IC50 values of 2.3 and 13.4 micrometer, respectively. Three-dimensional quantitative structure activity relationship (3D-QSAR) studies of comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed. Predictive 3D-QSAR models were obtained with q(2) values of 0.869 and 0.872 and r(2)(ncv) values of 0.983 and 0.993 for CoMFA and CoMSIA, respectively. These results demonstrate that CoMFA and CoMSIA models could be reliably used in the design of novel cytotoxic agents.
