Increased Rate of Palmitate Oxidation in Adults Female: Comparison with Peri-pubertal Young Female Rats.
- Author:
Se Young LEE
1
;
Jong Yeon KIM
;
Yong Woon KIM
;
So Young PARK
Author Information
1. Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea. sypark@medical.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Female;
Intra-abdominal fat mass;
Palmitate oxidation rate;
Skeletal muscle
- MeSH:
Adult*;
Animals;
Estrogens;
Female*;
Humans;
Insulin;
Intra-Abdominal Fat;
Liver;
Male;
Metabolism;
Muscle, Skeletal;
Plasma;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
2006;10(5):283-287
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although estrogen is known to play a role in fatty acid metabolism, it remains unclear whether fatty acid oxidation in mature female rats differs from fatty acid oxidation in peri-pubertal young rats. In this study, we measured fatty acid metabolism in the skeletal muscles and livers of 5 and 50 weeks old male and female rats. The rate of palmitate oxidation in the liver and gastrocnemius red in the 50-week-old female rats were elevated as compared to the 5-week-old females, whereas there were no differences in the male rats. The rate of palmitate oxidation in the gastrocnemius red was correlated inversely with intra-abdominal fat mass in the 5-week-old male and female rats, whereas the palmitate oxidation rate was positively correlated with fat mass in the liver and gastrocnemius red in the 50-week-old rats. HOMA-IR and plasma insulin levels were positively correlated with intra-abdominal fat mass in the pooled 50-week-old male and female rats, but this correlation was not apparent in 5-week-old rats. In summary, the rate of fatty acid oxidation measured in the middle-aged adult female rats was significantly higher than those measured in the peri-pubertal young female rats. This difference may be attributed to the influence of ovarian hormones.
