Inhibitory effect of quercetin and desferrioxamine in rat reflux esophagitis.
- Author:
Hyun Ju SONG
1
;
Bong Jin KIL
;
Ill Woong KIM
;
Young Sil MIN
;
Dong Seok KIM
;
Uy Dong SOHN
Author Information
1. Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul, South Korea. udsohn@cau.ac.kr
- Publication Type:Original Article
- MeSH:
Animals;
Deferoxamine*;
Esophagitis;
Esophagitis, Peptic*;
Gastric Acid;
Hydrogen-Ion Concentration;
Lipid Peroxidation;
Malondialdehyde;
Omeprazole;
Oxidative Stress;
Quercetin*;
Rats*
- From:The Korean Journal of Physiology and Pharmacology
2001;5(4):315-321
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was aimed to evaluate the effects of quercetin and desferrioxamine on the development of the reflux esophagitis induced surgically, on gastric secretion and on lipid peroxidation which is a marker of oxidative stress. Omeprazole was used as a positive control drug. Omeprazole significantly and dose-dependently prevented the development of reflux esophagitis, but quercetin or desferrioxamine prevented only at high dose. Omeprazole significantly and dose-dependently inhibited the gastric acid secretion (gastric volume, pH and acid output), but quercetin or desferrioxamine did not inhibit. Malonyldialdehyde content, the end product of lipid peroxidation, increased significantly after the induction of reflux esophagitis. Omeprazole prevented lipid peroxidation. Quercetin and desferrioxamine inhibited the lipid peroxidation independent of their actions on gastric secretion. This result indicates that omeprazole confirmed preventing effect of rat reflux esophagitis, but quercetin and desferrioxamine inhibited esophagitis by reduction of lipid peroxidation irrespective of gastric acid secretion.
