Expression Profiles of Immune-related Genes in Fluoxetine-treated Human Mononuclear Cells by cDNA Microarray.
- Author:
Hee Jae LEE
1
;
Sheng Yu JIN
;
Mee Suk HONG
;
Guang Zhe LI
;
Jong Woo KIM
;
Beom Sik KIM
;
Joo Ho CHUNG
Author Information
1. Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul 130-701, Korea. jhchung@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Fluoxetine;
Immune system;
cDNA microarray;
Peripheral blood mononuclear cell (PBMC)
- MeSH:
Apoferritins;
Cysteine;
DNA, Complementary*;
Fluoxetine;
Humans*;
Immune System;
Interleukins;
Oligonucleotide Array Sequence Analysis*;
Receptors, Interleukin-3;
Serotonin Uptake Inhibitors
- From:The Korean Journal of Physiology and Pharmacology
2003;7(5):279-282
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate the effect of fluoxetine, one of selective serotonin reuptake inhibitors (SSRIs), on the immune system, human peripheral blood mononuclear cells (PBMC) were treated with fluoxetine (10 7 M) for 24 h, and immune-related genes were analyzed by cDNA microarray. Expression of the immune- related genes such as CD107b (LAMP-2), CD47 receptor (thrombospondin receptor), CD5 antigen-like (scavenger receptor cysteine rich family), copine III (CPNE3), interleukin (IL) -18 (interferon-gamma- inducing factor), integrin alpha 4 (CD49d), integrin alpha L subunit (CD11a), IL-3 receptor alpha subunit, L apoferritin, and small inducible cytokine subfamily A (Cys-Cys) member 13 (SCYA13) was induced by fluoxetine. This result suggests that fluoxetine may affect the immune system, and provides fundamental data for the involvement of SSRIs on immunoregulation.
