Can Serum PSA Predict Prostate Volume in Men with Benign Prostatic Hyperplasia?.
- Author:
Dong Wook YU
1
;
Seung Chol PARK
;
Ill Young SEO
;
Joung Sik RIM
Author Information
1. Department of Urology, Medical Institute, Wonkwang University School of Medicine, Iksan, Korea. sc.park@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Prostate-specific antigen;
Age factors
- MeSH:
Age Factors;
Decision Making;
Humans;
Hyperplasia;
Linear Models;
Lower Urinary Tract Symptoms;
Male;
Oxidoreductases;
Prostate*;
Prostate-Specific Antigen;
Prostatic Hyperplasia*;
Prostatic Neoplasms;
Prostatitis;
ROC Curve
- From:Korean Journal of Urology
2005;46(6):574-578
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To analyze the ability of serum prostate specific antigen (s-PSA) to predict the prostate volume by characterizing the relationship between the prostate volume and serum PSA in men with benign prostate hyperplasia. MATERIALS AND METHODS: We evaluated 1,254 patients, with lower urinary tract symptoms, who had visited our hospital between Jan. 2002 and Aug. 2004. All patients with prostate cancer, prostatitis, and a history of prostatic surgery and alpha-blocker or 5-alpha reductase inhibitor medication were excluded from the study. The baseline s-PSA and prostate volume were determined using standard techniques. Pearson's correlation coefficient was used to analyze the relationship between the s-PSA and prostate volume, and a linear regression model to estimate the prostate volume. Receiver operating characteristics (ROC) curves were constructed to evaluate the ability of the s-PSA to predict cut-off values for assessing prostate enlargement. RESULTS: The analyses included 959 patients, with mean age, baseline s-PSA and prostate volume of 68.2 years, 3.4ng/ml and 34.4ml, respectively. The s-PSA and prostate volume increased with age. The prostate volume correlated positively with s-PSA (r=0.292, p<0.01). The linear regression analyses showed that the s-PSA and prostate volume had an age-dependent linear relationship. According to the ROC curves, the optimal s-PSA cut-off values for the entire study population were 1.5ng/ml to detect a prostate volume>30ml and 2.0ng/ml to detect a prostate volume>40ml. CONCLUSIONS: The prostate volume is strongly related to the s-PSA and age in men with benign prostatic hyperplasia (BPH). Since treatment outcomes and the risk of long-term complications depend on the prostate volume, the serum PSA may sufficiently estimate prostate enlargement to be useful in therapeutic decision making in men with BPH.
