Inhibitory Effects of Corni Fructus Extract on Angiogenesis and Adipogenesis.
10.4196/kjpp.2011.15.1.43
- Author:
Jae Ho HWANG
1
;
Jong Deog KIM
Author Information
1. College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Natural extract;
Anti-angiogenesis;
Anti-adipogenesis;
Orlistat;
Animal experiment
- MeSH:
Adipogenesis;
Animal Experimentation;
Animals;
Biological Agents;
Blotting, Western;
Cell Adhesion;
Cornus;
Diet;
Food, Formulated;
Hair;
Korea;
Lactones;
Mice;
Tea;
Weight Loss
- From:The Korean Journal of Physiology and Pharmacology
2011;15(1):43-51
- CountryRepublic of Korea
- Language:English
-
Abstract:
Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Corni fructus, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C. fructus extract (CFE) exhibits an angiogenesis inhibitory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added CFE. Moreover, a diet supplemented with CFE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that C. fructus may prove to be a useful anti-adipogenic compound, and these in vitro results may be reflected later under in vivo conditions.
