Regulation of DREAM Expression by Group I mGluR.
10.4196/kjpp.2011.15.2.95
- Author:
Jinu LEE
1
;
Insook KIM
;
So Ra OH
;
Suk Jin KO
;
Mi Kyung LIM
;
Dong Goo KIM
;
Chul Hoon KIM
Author Information
1. Department of Pharmacology, Yonsei University College of Medicine, Seoul 120-752, Korea. kimhoon@yuhs.ac
- Publication Type:Original Article
- Keywords:
Calcium;
DREAM;
Group I mGluR;
mGluR5;
mGluR1;
Pain
- MeSH:
Calcium;
Cytoplasm;
Dynorphins;
Methoxyhydroxyphenylglycol;
Neurons;
Potassium Channels;
Presenilins;
Proteins;
Receptors, Metabotropic Glutamate;
Up-Regulation
- From:The Korean Journal of Physiology and Pharmacology
2011;15(2):95-100
- CountryRepublic of Korea
- Language:English
-
Abstract:
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
