Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet.
10.4196/kjpp.2010.14.2.77
- Author:
Ying HAN
1
;
Mi Hyang DO
;
Mi Sun KIM
;
Eunhui SEO
;
Mi Kyoung PARK
;
Duk Kyu KIM
;
Hye Jeong LEE
;
Su Yeong SEO
Author Information
1. Department of Pharmacology, Dong-A University College of Medicine, Medical Science Research Center, Busan 602-714, Korea.
- Publication Type:Original Article
- Keywords:
Fenofibrate;
PPAR alpha;
Sprague-Dawley rats;
Hypercholesterolemia;
Aging
- MeSH:
Aging;
Animals;
Blood Glucose;
Body Weight;
Cholesterol;
Diet;
Eating;
Fasting;
Fenofibrate;
Humans;
Hypercholesterolemia;
Lipoproteins;
Male;
Plasma;
PPAR alpha;
Rats;
Rats, Sprague-Dawley;
Rodentia;
Triglycerides;
Water
- From:The Korean Journal of Physiology and Pharmacology
2010;14(2):77-81
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol. The aims of this study were: (1) to determine age-related changes in plasma lipid profiles, and (2) to determine the effect of fenofibrate, an activator of peroxisome proliferator activated receptor alpha (PPAR alpha), on plasma lipid profiles in normal rats on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water). Fenofibrate treatment lasted 5 weeks. There were no significant changes in daily food intake, blood glucose, and plasma TG level with age. Body weight, plasma TC, and FFA levels were significantly increased with age. Fenofibrate significantly decreased plasma concentrations of TC and FFA, which had been increased with age. However, fenofibrate did not influence the plasma concentration of TG, which had not increased with age. These results suggest that fenofibrate might have a novel role in preventing age-related hypercholesterolemia in SD rats on a normal diet.
