Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice.
- Author:
Hye Jin HAN
1
;
Un Ju JUNG
;
Hye Jin KIM
;
Byoung Seok MOON
;
Su Jung CHO
;
Yong Bok PARK
;
Dong Gun LEE
;
Myung Sook CHOI
Author Information
- Publication Type:Original Article
- Keywords: Grape pomace; Omija fruit; high-fat diet; lipid-regulating enzyme; antioxidant enzyme
- MeSH: Adipose Tissue, White; Adiposity; Animals; Body Weight; Cholesterol; Diet; Diet, High-Fat; Ethanol*; Fruit*; Humans; Lipid Metabolism*; Liver; Male; Mice; Mice, Obese*; Oxidative Stress; Plasma; Triglycerides; Vitis*; Weights and Measures
- From:Nutrition Research and Practice 2015;9(3):227-234
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVES: We investigated the effects of a combination of grape pomace (Vitis labrusca, Campbell Early) and Omija fruit (Schizandra chinensis, Baillon) ethanol extracts on lipid metabolism and antioxidant defense system in diet-induced obese mice. MATERIALS/METHODS: Forty male C57BL/6J mice were divided into four groups and fed high-fat diet (control group, CON) or high-fat diet added 0.5% grape pomace extract (GPE), 0.05% Omija fruit extract (OFE) or 0.5% GPE plus 0.05% OFE (GPE+OFE) for 12 weeks. RESULTS: In contrast to the GPE- or OFE-supplemented groups, the GPE+OFE group showed significantly lower body weight and white adipose tissue weights than the CON group. Moreover, GPE+OFE supplementation significantly decreased plasma total cholesterol and increased the plasma HDL-cholesterol/total-cholesterol ratio (HTR) compared to the control diet. The hepatic triglyceride level was significantly lower in the GPE+OFE and GPE groups by increasing beta-oxidation and decreasing lipogenic enzyme compared to the CON group. Furthermore, GPE+OFE supplementation significantly increased antioxidant enzyme activities with a simultaneous decrease in liver H2O2 content compared to the control diet. CONCLUSIONS: Together our results suggest that supplementation with the GPE+OFE mixture may be more effective in improving adiposity, lipid metabolism and oxidative stress in high-fat diet-fed mice than those with GPE and OFE alone.
